Director, Safety Science & Pharmacovigilance
Location: Hybrid – North London (2 days on-site, 3 days remote)
Industry: Global Pharmaceutical
Salary: £80,000-£95,000
CPL Life Sciences is proud to be partnered with a world-renowned global pharmaceutical company seeking an experienced Director of Safety Science & Pharmacovigilance. This senior position offers a unique opportunity to provide strategic and hands-on leadership across the full lifecycle of investigational and marketed products.
The successful candidate will play a key operational role in driving safety science deliverables across clinical development and post-marketing activities. This is not a purely oversight role — we are looking for a Director who is comfortable rolling up their sleeves, managing complex safety deliverables, and leading by example within cross-functional teams.
Key Responsibilities:
Provide strategic and hands-on leadership across early and late-phase development and post-marketing safety activities
Lead signal detection and evaluation, contributing to risk-benefit assessments and mitigation strategies
Oversee and contribute directly to the preparation of aggregate safety reports (e.g., DSURs, PBRERs) and regulatory submissions (e.g., INDs, NDAs, MAAs)
Ensure high-quality operational delivery of safety documents and regulatory responses
Manage safety-related activities for individual case safety reports (ICSRs) in collaboration with PV operations teams
Provide expert input into the development, review, and maintenance of core safety documents, including RMPs and safety labels
Act as the safety lead on study teams and safety governance committees (e.g., iDMCs, IMCs)
Drive collaboration with internal stakeholders and external partners to ensure compliance, efficiency, and scientific rigor in safety deliverables
Mentor and guide more junior safety scientists, contributing to a high-performance safety culture
No line management responsibilities but strong teamwork and positive communication is essential
Essential experience:
Clinical and post-marketing experience
Hands on operational delivery of signal detection, aggregate reporting and risk management plans
Strong regulatory knowledge across a global health authorities (EMA, FDA, MHRA)
Advanced degree is preferred, but not essential